Pharmacological action of Nizoral Shampoo
Nizoral Shampoo is antifungal agent for topical use, derivative of imidazoldioksolane. It has a fungicidal and fungistatic action. The mechanism of action is inhibition of the biosynthesis of ergosterol, and changes in membrane of lipid composition of fungi. It is active against dermatophytes: Trichophyton, Microsporum, Epidermophyton floccosum; yeast and yeast-like fungus Candida, Pityrosporum. The drug rapidly reduces flaking and itching, associated with dandruff, seborrheic dermatitis and pityriasis versicolor.
Statement of Nizoral Shampoo
Treatment and prevention of fungal infections of the skin of the scalp:
- Dandruff;
- Seborrheic dermatitis;
- Chromophytosis.
Dosage regime of Nizoral Shampoo
Shampoo is applied to the affected area for 3-5 minutes, then washed off with water. In the treatment of dandruff and seborrheic dermatitis, shampoo is used 2 times a week for 3-4 weeks, with scaly skin disease - daily for 5 days. For the prevention of dandruff and seborrheic dermatitis Nizoral Shampoo used 1 time per week or 1 every 2 weeks, with scaly skin disease - 1 times / day for 3 consecutive days before the onset of summer.
Side effect of Nizoral Shampoo
Local reactions: - skin irritation, itching, contact dermatitis, increased oiliness or dryness of hair, increased hair loss and in some cases - to change the color of the hair (in patients with chemically damaged or gray hair). Typically, the drug was well tolerated.
Contraindications for Nizoral Shampoo
- Hypersensitivity to the drug.
Pregnancy and lactation while use of Nizoral Shampoo
Nizoral shampoo during pregnancy and lactation is not contraindicated, because with topical ketoconazole practically it is not absorbed into the systemic circulation.
Cautions for Nizoral Shampoo
Avoid getting product into eyes. After contact with the shampoo in the eye, rinse with water. In appointing the shampoo Nizoral patients treated with topical corticosteroids for a long time, to avoid withdrawal should continue to use the therapy shampoo Nizoral, followed by the gradual abolition of corticosteroids over 2-3 weeks. Seborrheic dermatitis and dandruff are often accompanied by increased hair loss. In rare cases, increased hair loss was noted when applying the shampoo Nizoral.
Overdose of Nizoral Shampoo
Shampoo is for external use, while ketoconazole practically not absorbed into the systemic circulation, the development of symptoms of overdose are unlikely. Treatment: Accidental ingestion of special measures are required, are shown only supportive measures. Prohibited conduct to induce vomiting and gastric lavage.
Drug Interactions
As with topical ketoconazole shampoo nizoral practically not subjected to systemic absorption, interactions with other drugs is unlikely. The drug should be stored at a temperature of 15 ° to 25 ° C, out of reach of children. Shelf life - 3 years. The drug is approved for use as a non-prescription medicines.
